| The herb is considered as one of the most effective remedies for treating gastrointestinal diseases such as dysentery and diarrhea.
Holarrhenais also useful in toning up the entire digestive track and several Indian tribes have been using the plant in ailments such as anemia, epilepsy, stomach pain and cholera. The bark extract of the tree has been considered as best anthelmintic and is also used to treat various skin diseases.
There are many health diseases that can effectively be treated with various preparation of the drug Kutaja or Holarrhenabut here are some of those conditions that can be cured very effectual manner –
- Any dysentery or diarrhea (especially chronic)
- Intestinal and hepatic amebiasis
- Digestive problems
- Minor skin infections
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Serving size: 2 Vegi caps
Servings per container: 30
Each 500 mg capsule contains: Kutaj
Dosage: 1-2 Capsules two times a day after meal or or as directed by your health practitioner.
According to one study, Holarrhenafrom the bark is capable to kill free living amoebae and it also kills entamoeba histolytica in the dysenteric stools of experimentally infected kittens The herb is markedly lethal to the flagellate protozoon [1 and 2].
Conessine or Kutaja possesses some properties that fight effectively against the mycobacterium tuberculi and hence, it can be used treating pulmonary tuberculosis [3].
Conkurchine hydrochloride, found in Kutaja or Conessine is considered to be hypotensive and vasodilator [4].
The bark of this wonderful drug is used as an astringent, anthelmintic, anti-dontalgic and stomachic. It also has certain unique properties such as febrifuge, anti-dropsical and diuretic. Kutaja or Conessine has bee used to treat various health ailments such as piles, colic, dyspepsia, chest affections and as a remedy in diseases of the skin and spleen [5].
Kutaja is potent drug for treating various gastrointestinal canal’s disorders especially helping to cure amoebic dysentery and other gastric disorders [6].
Kutaja or Conessine is useful herb treating many diseases but it is most powerful against diarrhea, indigestion, flatulence and colic [7].
References:
- Indian J. Chem., 1981, 20B: 62.
- Chopra, R.N,: Indigenous Drugs of India, Academic Publishers, Calcutta (1982).
- J.Pharm. (London), 1049, 1:340.
- Proc. Rajasthan Acad. Sci., 1961, 8:94.
- Dictionary of Indian Medicinal Plants,CIMAP, Lucknow(1992)
- Singh, K.P.: Ancient Sci. Life 5:228 (1986).
- Selected Medicinal Plants of India, CHEMEXCIL, Mumbai (1982).
As broad-spectrum antibacterial activity: In search of broad-spectrum antibacterial activity from traditionally used Indian medicinal plants, 66 ethanolic plant extracts were screened against nine different bacteria. Of these, 39 extracts demonstrated activity against six or more test bacteria. Twelve extracts showing broad-spectrum activity were tested against specific multidrug-resistant (MDR) bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and extended spectrum beta-lactamases (ESbetaL)-producing enteric bacteria. In vitro efficacy was expressed in terms of minimum inhibitory concentration (MIC) values of plant extracts. MIC values ranged from 0.32-7.5 mg/ml against MRSA and 0.31-6.25 mg/ml against ESbetaL-producing enteric bacteria. The overall activity against all groups of bacteria was found in order of Plumbago zeylanica > Hemidesmus indicus > Acorus calamus > Camellia sinensis > Terminalia chebula > Terminalia bellerica > Holarrhena antidysenterica > Lawsonia inermis > Mangifera indica > Punica granatum > Cichorium intybus and Delonix regia. In addition, these extracts showed synergistic interaction with tetracycline, chloramphenicol and ciprofloxacin against S. aureus and/or Escherichia coli. The ethanolic extracts of more than 12 plants were found nontoxic to sheep erythrocytes and nonmutagenic, determined by Ames test using Salmonella typhimurium test strains (TA 97a, TA 100, TA 102 and TA 104). Based on above properties, six plants-Plumbago zeylanica, Hemidesmus indicus, Acorus calamus, Punica granatum, Holarrhena antidysenterica and Delonix regia-were further subjected to fractionation-based study. Ethyl acetate, acetone and methanol fractions of more than six plants indicated that the active phytocompounds were distributed mainly into acetone and ethyl acetate fractions, whereas they were least prevalent in methanol fractions as evident from their antibacterial activity against MDR bacteria. Gram-positive and Gram-negative MDR bacteria are almost equally sensitive to these extracts/fractions, indicating their broad-spectrum nature. However, strain- and plant extract-dependent variations in the antibacterial activity were also evident. Time-kill assay with the most promising plant fraction Plumbago zeylanica (ethyl acetate fraction) demonstrated killing of test bacteria at the level lower than its MIC. Further, identification of active constituents in each fraction and their additive and synergistic interactions are needed to exploit them in evaluating efficacy and safety in vivo against MDR bacteria (Methods Find Exp Clin Pharmacol. 2007 Mar; 29(2):79-92 for Antibacterial properties of traditionally used Indian medicinal plants by Aqil F, Ahmad I. at Department of Agricultural Microbiology, Aligarh Muslim University, Aligarh, India.)
As Anti-diarrheal and Anti-dysentery activity: The alkaloids from the ethanolic extract of H. antidysenterica seeds were evaluated for their antibacterial activity against clinical isolates of enteropathogenic Escherichia coli (EPEC) in vitro, and their anti-diarrheal activity on castor oil-induced diarrhea in rats, in vivo. The plasmid DNA, whole cell lysate and outer membrane protein profile of a clinical isolate of EPEC was determined in presence of alkaloids of H. antidysenterica. The disc diffusion and agar well diffusion methods were used to evaluate the antibacterial efficacy. The alkaloids showed strong antibacterial activity against EPEC strains. In castor oil-induced diarrhea, alkaloids reduced the diarrhea with decrease in the number of wet faeces in pretreated rats at a dose of 200-800 mg/kg. The loss of plasmid DNA and suppression of high molecular weight proteins were observed on alkaloids treatment. Taking into account the multiple antibiotic resistance of EPEC, the results suggest usefulness of alkaloids of H. antidysenterica seeds as antibacterial and anti-diarrheal agents. ( Indian J Exp Biol. 2004 Jun;42(6):589-94. for Antibacterial and antidiarrhoeal effects of alkaloids of Holarrhena antidysenterica WALL by Kavitha D, Shilpa PN, Devaraj SN. At Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India)
Holarrhenais a deciduous laticiferous shrub or can be considered as a small tree. The tree grows up to three meters high. The tree has short stem that has pale bark and several branches. The ovate to obtusely acuminate leaves are 10-20 cm in length. Its leaf stalks are very short.
The Holarrhenahas white flowers that appear in corymb-like cymes, 5-15 cm across and present at the end of the tree’s branches. Kutaja’s flowers of have five white petals 2-3 cm in length that will turn creamish yellow as they grow. The tree’s flowers have oblong petals that are rounded at the tip.
If more specified, H.antidysenterica is a broad-leafed shrub or small tree. The tree’s bark is rather rough, pale brownish or grayish and the leaves are opposite, subsessile, elliptic or ovate-oblong, membranous and the flowers are white, in terminal corymbose cymes; the follicles, divaricate, cylindric and generally having white spots; the seeds are light brown in color.
Supplement Facts:
Serving size: 2 Vegi caps
Servings per container: 30
Each 500 mg capsule contains: Kutaj
Dosage: 1-2 Capsules two times a day after meal or or as directed by your health practitioner.
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